Gilead Sciences has launched a new 10-year, $100 million program to support organizations working to address the HIV/AIDS epidemic in the Southern United States. Under the COMPASS Initiative—short for Commitment to Partnership in Addressing HIV/AIDS in Southern States—Gilead will partner with the Emory University Rollins School of Public Health, the University of Houston Graduate College of Social Work, and the Southern AIDS Coalition, which will identify and provide funding to local organizations that are committed to addressing the epidemic throughout the region. The initiative has a threefold mission: to build capacity and increase knowledge sharing among community-based, underfunded organizations in Southern states; to explore interventions that appropriately respond to patients’ needs, including the bundling or reframing of mental health care, as well as the intersection between substance use, the opioid epidemic, and HIV/AIDS; and to fund awareness and anti-stigma campaigns. The ultimate goal is to dramatically increase the reach of these organizations working to address the epidemic in the region, and improve the lives of those affected by HIV/AIDS.